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Women's top seed and 2016 finalist Karolina Pliskova of the Czech Republic kicks off the action in Arthur Ashe Stadium on Day 8 at the Open, facing off against American Jennifer Brady in the fourth round at 11 a.m. ET. Brady, ranked No. 91 in the world, is making her second fourth-round appearance at a Grand Slam tournament this year, having also reached the round of 16 at the Australian Open in January.
Men's No. 1 Rafael Nadal is the second match on in Ashe, and the two-time champion will be looking to secure a spot in the quarterfinals when he takes on Ukraine’s Alexandr Dolgopolov. Dolgopolov, currently ranked No. 64, has reached one Slam quarterfinal in his career at the 2011 Australian Open and has equaled his best performance ever in New York by reaching the fourth round, also in 2011.
Rounding out play in Ashe for the day session, No. 20 seed and home-country favorite CoCo Vandeweghhe will face off against Czech Lucie Safarova. Vandeweghe has reached her career-best result at the Open this year, advancing past the third round for the first time.
In other singles action Monday, No. 9 seed David Goffin of Belgium will take on unseeded Russian Andrey Rublev in the second match in Louis Armstrong Stadium, and then Russia’s Daria Kasatkina will follow against Kaia Kanepi of Estonia.
2009 US Open champion Juan Martin del Potro is also on the schedule and will play No. 6 seed Dominic Thiem fourth in Grandstand.
Five-time champion Roger Federer will open up night-session play in Ashe, taking on No. 33 seed Philipp Kohlschreiber of Germany in the fourth round. No. 15 seed Madison Keys of the U.S. will follow, squaring off against No. 4 seed Elina Svitolina of Ukraine.

(3) Roger Federer vs. (33) Philipp Kohlschreiber
Federer did not look in the same form that has helped him win two Grand Slam titles this season in his first two matches in Flushing Meadows. Both Frances Tiafoe and Mikhail Youzhny pushed the "Swiss Maestro" to five sets. But a straight-sets, rather uncomplicated victory over the tricky Feliciano Lopez should leave fans of the 19-time major champion optimistic. It will be a completely different matchup for Federer against No. 33 Philipp Kohlschreiber, who will use the angles of the court with far more topspin than Lopez to work the point rather than rush the net. The third seed has an 11-0 lead in the duo's head-to-head, and don't expect that to change. Federer will take another step toward a possible semifinal against Rafael Nadal in straight sets.
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(9) David Goffin vs. Andrey Rublev
Those who don't know Rublev likely will after this match. The 19-year-old is one of the best pure ball-strikers pound-for-pound in the world, and you will never find that he lacks intensity on the court. It should be an interesting clash of styles with Goffin, another excellent ground-stroker who can counterpunch with the very best. The Belgian will look to frustrate Rublev and force the Russian out of his rhythm. Expect him to try to take the baseline away from his younger opponent when possible to play on his terms rather than the Russian's. Rublev has only dropped one set in singles or doubles this US Open, against Damir Dzumhur. And if he maintains his composure once again, look for the teenager to back up his upset of No. 7 Grigor Dimitrov with a tough five-set victory against Goffin.

WOMEN
(1) Karolina Pliskova vs. Jennifer Brady
Pliskova has not looked her best over the course of the tournament's first week. If it wasn't for saving match point in her third-rounder against No. 27 Zhang Shuai, the Czech would already be on her way home, with no chance of maintaining her No. 1 ranking. One thing is for sure: former UCLA Bruin Jennifer Brady will not be afraid of going for her shots against a fellow big-hitter like Pliskova, especially on the forehand wing. One of two things will happen Monday: Brady will earn the win of her life or Pliskova will return to or near the form that got her to last year's US Open final. While Brady's run in New York has capped off an excellent first season of Grand Slam main draws, take the latter. Pliskova in two.
Daria Kasatkina vs. Kaia Kanepi
In general, this matchup will be similar to Kasatkina's last match, and entirely different for Kanepi. The Estonian faced a fellow big-hitter in Naomi Osaka, surviving a three-set battle in the third round. Kasatkina will attempt to put as many balls back in play as possible and use Kanepi's aggression against her. She did a good job of that after a slow start against French Open champion Jelena Ostapenko, eventually ousting arguably the most aggressive player on tour, 6-3, 6-2. Kasatkina and Kanepi have never played before, but expect Kasatkina to advance to her first Grand Slam quarterfinal in straight sets.